Inflammation indices in chronic stable coronary artery disease
Salazar, Juan; Inciarte, Douglas; Briceño, Soledad; Bracho, Mayela; Esis, Carlos; Silva, Egle; Añez, Roberto
ABSTRACT
Introduction: coronary artery disease (CAD) is a chronic inflammatory disorder of multifactorial origin, with inflammation being a key pathophysiological aspect.
Objective: to determine the relationship between inflammatory indices and the severity of chronic CAD in subjects undergoing cardiac catheterization at the Institute of Cardiovascular Disease Research of the University of Zulia.
Material and methods: the research was descriptive, cross-sectional, and correlational, with a non-experimental design. The sample was selected through simple random sampling, with subjects over 18 years of age with chronic coronary syndrome who had inflammatory indices quantified and the SYNTAX score determined to assess the severity of CAD.
Results: of the 73 subjects evaluated, 50.7% (n = 37) were men, the overall average age was 59.5 ± 7.7 years, 83.6% (n = 61) were hypertensive, and 68.5% (n = 50) had a previous acute coronary syndrome. A higher average of platelets (376.1 ± 85.6 × 10
3/mm
3), platelet-lymphocyte ratio (PLR) (144.9 ± 54.7), and systemic immune-inflammation index (SIII) (703.2 ± 335.9) was observed in subjects with a SYNTAX score ≥ 33. A positive correlation was found between PLR and the SYNTAX score (r = 0.61; p < 0.01) and between the SIII and the SYNTAX score (r = 0.55; p < 0.01). In the multiple linear regression analysis, the SIII was the index most independently related to the SYNTAX score (β = 0.64; p < 0.01).
Conclusions: the study found that the SIII was significantly associated with a higher severity of chronic CAD, as indicated by the SYNTAX score. This association was observed independently of other inflammatory and lipid factors.
