2026, Supplement 1
Cardiovasc Metab Sci 2026; 37 (S1)
Multisociety Mexican Consensus on the integration of polygenic risk in cardiovascular risk stratification: implications for precision cardiovascular medicine in Mexico
Parcero-Valdés, Juan José; Magaña-Serrano, Antonio; Arias-Mendoza, María Alexandra; Narváez-Oriani, Carlos; Altamirano-Cardoso, Esmeralda; Barrios, Vivencio; Alcocer Díaz-Barreiro, Luis; Pavia-López, Abel; Gómez-Álvarez, Enrique
ABSTRACT
Introduction: cardiovascular disease remains the leading cause of mortality in Mexico, accounting for approximately one in four deaths nationwide. The epidemiological transition is characterized by a high prevalence of obesity, type 2 diabetes mellitus, hypertension, and atherogenic dyslipidemia from early stages of life, resulting in prolonged cumulative cardiometabolic exposure and earlier onset of atherosclerotic events. Traditional risk models, based on phenotypic variables and strongly dependent on chronological age, tend to underestimate biological susceptibility in younger individuals. Objective: to establish a multisociety position on the clinical use of Polygenic Risk Scores (PRS) in Mexico and to define a national implementation strategy linked to real-world evidence generation through the PRS-MX Registry. Material and methods: this consensus document was developed through a structured literature review and a modified Delphi methodology involving national experts in clinical cardiology, interventional cardiology, lipidology, genetics, and public health. Results: PRS is independent of traditional risk factors, improves risk reclassification in primary prevention, and identifies individuals with greater absolute benefit from lipid-lowering therapies. A three-dimensional model integrating phenotype, anatomy, and genotype is proposed. Conclusions: selective implementation of PRS in Mexico represents a step toward precision cardiovascular medicine and should be carried out in a stepwise manner linked to national evidence generation.